study, the overall prevalence of dyslipidemia in normal weight adolescents was 14.2%, which increased to 42.9% in obese youth. 5 According to a large population-based U.S. 4 Childhood body mass index (BMI) showed strong tracking to adulthood, and childhood BMI was independently related with carotid intima-media thickness (cIMT) in adulthood. 2, 3Īccording to a study that included 230,000 Norwegian adolescents, adolescent obesity was associated with increased mortality in middle age from several causes, including ischemic heart disease. 2 Childhood obesity can adversely affect many organs and increases the risk of chronic diseases, including dyslipidemia, diabetes, and cardiovascular disease (CVD). 1 The increasing prevalence of obesity in children and adolescents is considered as one of the most series public health concerns in this century. Obesity results from chronic energy imbalance involving dietary intake and physical activity. Keywords: Hypertriglyceridemia, Obesity, Child The primary approach to lower TG in children includes dietary and lifestyle modifications however, children with severe hypertriglyceridemia should also be referred to a pediatric lipid specialist. Recent guidelines recommend universal lipid screening with nonfasting non-HDL-C measurement in children at 9–11 years of age however, fasting lipid profiles should be measured in obese children and overweight adolescents and in those with high non-HDL-C in universal screening. Recently, the TG/high-density lipoprotein cholesterol (HDL-C) ratio was recognized as a marker of structural vascular changes and insulin resistance in obese youth. The prevalence of hypertriglyceridemia increases in overweight or obese children and is associated with other cardiometabolic risk factors. Adipose tissue dysfunction, including impaired adipocyte TG storage and release of fatty acids, mediates the development of obesity-related complications. However, simultaneous measurement of all remnants has not yet been established, and plasma TG level can be used as a useful marker of remnant cholesterol. Results from genetic studies suggest that TG and TG-rich lipoproteins and, more specifically, remnant cholesterol are in the causal pathway of cardiovascular disease. Hypertriglyceridemia is common in obese children and adolescents, and elevated triglyceride (TG) level is a known biomarker of cardiometabolic risk. The increasing prevalence of obesity in children and adolescents is a serious public health concern.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |